My OraStrip

PDX Biotech

The Science Behind OraStrip

Periodontal disease is an infection of the gingiva caused by anaerobic microorganisms – such as Porphyromonas and Treponema species(1). When such microbes are present in subgingival biofilms (below the gum line) they are known to produce large quantities of metabolic products called thiols(2) that can disrupt gum tissue and destroy healthy bone by inducing bone loss.

OraStrip QuickCheck Canine directly measures the concentration of thiols in canine oral fluid from the gingival margin and provides a visual signal related to the thiol concentration. This assists in detecting and monitoring periodontal disease activity by indicating the extent of periodontal infection.

The lip of the canine patient is lifted and the pad of the strip is gently glided along the maxillary facial gingival margin (upper gum line). The color developed on the pad is then compared to the color chart on the OraStrip comparator card. The intensity of the color developed on the strip is directly related to the concentration of thiols in the sample, and the concentration of thiols indicates the extent of periodontal infection.

(1) Isogai H, Kosako Y, Benno Y, Isogai E (1999). Zentralbl Veterinarmed B. 46(7):467-73; Hardham J, Dreier K, Wong J, Sfintescu C, Evans RT (2005). Vet Microbiol. 106(1-2):119-28; Nordohff M, et al (2008). Veterinary Microbiol. 127:334-342.

(2) Yoshida A, Yoshimura M, Ohara N, Yoshimura S, Nagashima S, Takehara T, Nakayama K (2009). J Periodontol. 80(11):1845-51; Chen W, Kajiya M, Giro G, Ouhara K, Mackler HE, Mawardi H, Boisvert H, Duncan MJ, Sato K, Kawai T (2010). Biochem Biophys Res Commun. 391(1):645-50.

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